Search results for "Cell Nucleus Shape"

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Is Autophagy Altered in the Leukocytes of Type 2 Diabetic Patients?

2015

It is unknown whether autophagy is altered in the leukocytes of type 2 diabetes (T2D) patients and whether oxidative and endoplasmic reticulum (ER) stresses regulate this mechanism. We studied anthropometric and metabolic parameters and evaluated oxidative stress, chromatin condensation, ER stress, and autophagy parameters in leukocytes of 103 T2D patients versus 109 sex- and age-matched controls. Patients showed increases in glucose, insulin, homeostasis model assessment of insulin resistance, and glycated hemoglobin (HbA1c) compared with controls (p < 0.001). Leukocytes displayed enhanced total and mitochondrial reactive oxygen species (ROS), reduced mitochondrial mass, and increased chro…

Malemedicine.medical_specialtyCell Nucleus ShapePhysiologymedicine.medical_treatmentClinical BiochemistryBiologymedicine.disease_causeBiochemistryInsulin resistanceInternal medicinemedicineAutophagyLeukocytesHumansMolecular BiologyEndoplasmic Reticulum Chaperone BiPGeneral Environmental ScienceAgedchemistry.chemical_classificationReactive oxygen speciesATF6Endoplasmic reticulumInsulinAutophagyCell BiologyMiddle Agedmedicine.diseaseEndoplasmic Reticulum StressOxidative StressEndocrinologychemistryDiabetes Mellitus Type 2Case-Control StudiesUnfolded protein responseGeneral Earth and Planetary SciencesFemaleReactive Oxygen SpeciesOxidation-ReductionOxidative stressSignal TransductionAntioxidantsredox signaling
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